کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8686476 1580690 2011 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Properly scaled and targeted AAV2-NRTN (neurturin) to the substantia nigra is safe, effective and causes no weight loss: Support for nigral targeting in Parkinson's disease
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Properly scaled and targeted AAV2-NRTN (neurturin) to the substantia nigra is safe, effective and causes no weight loss: Support for nigral targeting in Parkinson's disease
چکیده انگلیسی
► Very high doses of AAV2-NRTN can be safely administered to the substantia nigra (SN), causing no toxicity. ► For translational purposes, a wide 'therapeutic index' exists, for very low doses provide neuroprotection. ► The effect on body weight reported by others as 'dangerous' requires a very high dose of vector. ► The high vector dose that affects body weight does so via significant mistargeted (non-SN) protein. ► Data support targeting the substantia nigra with AAV-NRTN in Parkinson's patients to maximize neurotrophic response.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Disease - Volume 44, Issue 1, October 2011, Pages 38-52
نویسندگان
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