کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8721428 1589404 2018 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
B cell phenotypes, signaling and their roles in secretion of antibodies in systemic lupus erythematosus
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
B cell phenotypes, signaling and their roles in secretion of antibodies in systemic lupus erythematosus
چکیده انگلیسی
B cells play a pivotal role in the initiation and perpetuation of SLE. Because SLE is molecularly and clinically heterogeneous, efficacious targeted therapy to clinical remission has not yet been established in SLE. We have found i) statistical clustering between Tfh cells and class-switched memory B cells and the upregulated transition from CXCR5+ IgM memory B cells to CXCR3+ class-switched memory B cells in SLE by 8-color flow cytometry, ii) the involvement of Syk, Btk and JAK in the activation and differentiation of B cells in SLE, iii) SLE patients was divided to 3 groups based on immunophenotypic analysis and statistical analysis and patients in the Tfh/class-switched B cell-dominant group were most refractory to conventional therapies although 3 groups had similar clinical features. Thus, novel therapies targeting Tfh-memory B cell interaction are anticipated in certain subpopulation of SLE patients, which leads to the precision medicine in SLE.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 186, January 2018, Pages 21-25
نویسندگان
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