کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8723003 | 1589613 | 2018 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of Short-Term Calcium Supplementation in Children and Adolescents with Phenylketonuria
ترجمه فارسی عنوان
اثرات مکمل کوتاه مدت کلسیم در کودکان و نوجوانان با فنیلکتونوری
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
غدد درون ریز، دیابت و متابولیسم
چکیده انگلیسی
Reduction of bone mineral density and the risk of osteopenia have been reported to occur in phenylketonuria (PKU) patients. This study aimed to evaluate the short-term effects of calcium supplementation in phenylketonuric children and adolescents. The study included 18 patients with PKU aged 5-18 yr (61% male) under clinical and nutritional treatment. Evaluation of food intake, anthropometry, and biochemical and phalangeal quantitative ultrasound were performed before (phase 1) and after (phase 2) calcium supplementation (1000âmg/d) for 34âd. Statistical analysis was performed using t test for paired samples, Wilcoxon's test, and McNemar's test (pâ<0.05). There was an inadequate intake of phosphorus and vitamin D, the same occurring with serum concentrations of these nutrients. About 50% of the patients had an accumulation of adipose tissue measures, with a negative correlation between Z-score, body mass index, and phalangeal quantitative ultrasound (amplitude-dependent speed of sound [AD-SoS]). There was a significant difference in urinary phosphorus excretion with higher values before supplementation. Comparison of the two phases revealed significantly higher AD-SoS values after the supplementation (pâ=â0.017). The reduction in phosphorus excretion associated with increased AD-SoS between the two phases suggested increased bone formation, and showed no negative effects in relation to short-term calcium supplementation in children and in adolescents with PKU.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Densitometry - Volume 21, Issue 1, JanuaryâMarch 2018, Pages 48-53
Journal: Journal of Clinical Densitometry - Volume 21, Issue 1, JanuaryâMarch 2018, Pages 48-53
نویسندگان
Nancy Y.Y. Tanaka, Marlene F. Turcato, Carolina F. Nicoletti, Carla B. Nonino, Luciana D. Martins, Odilon Iannetta, Carlos T. Guerreiro, Gisele G. Santos, Júlio S. Marchini,