کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8786278 | 1601131 | 2017 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Recommendations for Randomised Trials in Surgical Oncology
ترجمه فارسی عنوان
توصیه هایی برای آزمایش های تصادفی در انکولوژی جراحی
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کلمات کلیدی
سرطان روده بزرگ، انکولوژی، بیمار و نمایندگی عمومی، روش تحقیق، عمل جراحی، آزمایشات تصادفی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
چکیده انگلیسی
Trials of surgical procedures in the treatment of malignant disease face a unique set of challenges. This review aimed to describe recommendations for the design, delivery and reporting of randomised trials in surgical oncology. A literature search was carried out without date limits to identify articles related to trial methodology research in surgery and surgical oncology. A narrative review was framed around two open National Institute of Health Research portfolio trials in colon and rectal cancer: the STAR-TREC trial (ISRCTN14240288) and the ROCCS trial (ISRCTN46330337). Twelve specific challenges were highlighted: standardisation of technique; pilot and feasibility studies; balancing treatments; the recruitment pathway; outcome measures; patient and public representation; trainee-led networks; randomisation; novel techniques and training; learning curves; blinding; follow-up. Evidence-based recommendations were made for the future design and conduct of surgical oncology trials. Better understanding of the challenges facing trials in the surgical treatment of cancer will accelerate high-quality evaluation and rapid adoption of innovation for the benefit of patient care.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Oncology - Volume 29, Issue 12, December 2017, Pages 799-810
Journal: Clinical Oncology - Volume 29, Issue 12, December 2017, Pages 799-810
نویسندگان
J.C. Glasbey, E.L. Magill, K. Brock, S.P. Bach,