کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8816102 1608279 2018 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reduced saccadic velocity and pupillary width in young onset Parkinson's disease
ترجمه فارسی عنوان
کاهش سرعت ساکاتیک و عرض شاخه ای در بیماری مبتلا به پارکینسون جوان
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی
Patients with Young onset Parkinson disease patients (YODP) are individuals with motor complications identical to late onset Parkinson's disease (PD) but onset in early age. YOPD is a specific subgroup of PD and their performance on saccadic eye movements is not well established. This study evaluated saccadic eye movements in patients with YOPD ( < 40 years at onset of illness). Eye movements were recorded during saccadic eye movement tasks, induced by presentation of a visual target and reflexive saccadic task was administered. YOPD patients showed reduced saccadic velocity on reflexive saccadic task (Gap task) as compared to their age matched healthy controls. Additionally, pupil width in gap period and at saccade onset was measured. Pupil width was significantly smaller in patients with YOPD as compared to control subjects. Reduced saccadic velocity implies that Parkinson's disease affects saccadic circuitry in patients with YOPD reflecting impaired circuitry at the brainstem level. The reduced pupillary response in gap condition is attributed to deficits in motor preparedness in patients compared to controls.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurology, Psychiatry and Brain Research - Volume 27, February 2018, Pages 17-20
نویسندگان
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