کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8839014 | 1613220 | 2018 | 46 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The protective effect of 20(S)-protopanaxadiol (PPD) against chronic sleep deprivation (CSD)-induced memory impairments in mice
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کلمات کلیدی
Chronic sleep deprivationMODPPDMWMCSDMCAONORTBARSLPOGSHSIACATOLR20(S)-Protopanaxadiol - 20 (S) -ProtopanaxadiolROS - ROSmiddle cerebral artery occlusion - انسداد شریان (سرخرگ) مغزی میانیCognitive improvement - بهبود شناختیlong-term potentiation - تقویت درازمدتLTP - تقویت طولانی مدت یا LTP Oxidative stress - تنش اکسیداتیوCNS - دستگاه عصبی مرکزیSOD - سدSuperoxide dismutase - سوکسوکس دیسموتازcentral nervous system - سیستم عصبی مرکزیdiscrimination index - شاخص تبعیضNovel object recognition - شناسایی شیء رمانCortex - قشرModafinil - مادافینیلSleep deprivation - محرومیت از خوابMice - موشHippocampus - هیپوکامپ thiobarbituric acid reactive substance - واکنش پذیر اسید تیوباربیتوریکLipid peroxidation - پراکسیداسیون لیپیدCatalase - کاتالازMorris water maze task - کار موریس آب موریسGlutathione - گلوتاتیونReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
Sleep deprivation (SD) is associated with oxidative stress that causes learning and memory impairment. 20(S)-Protopanaxadiol (PPD), one of the protopanaxadiol-type saponins, has antioxidant and neuroprotective effect. This study was designed to research the protective effect of PPD against cognitive deficits induced by chronic sleep deprivation (CSD) in mice. The CSD model was induced by subjecting the mice to our self-made Sleep Interruption Apparatus (SIA) continuously for 14â¯days. The memory enhancing effects of PPD were evaluated by behavioral tests and the related mechanism was further explored by observing the oxidative stress changes in the cortex and hippocampus of mice. The results revealed that PPD (20 and 40â¯Î¼mol/kg, i.p.) administration significantly improved the cognitive performance of CSD model mice in object location recognition experiment, novel object recognition task and Morris water maze test. Furthermore, PPD effectively restored the levels/activities of antioxidant defense biomarkers in the cortex and hippocampus, including the superoxide dismutase (SOD) enzyme activity, catalase (CAT) enzyme activity, glutathione (GSH), and lipid peroxidation (LPO). In conclusion, PPD could attenuate cognitive deficits induced by CSD, and the neuroprotective effect of PPD might be mediated by alleviation of oxidative stress. It was assumed that PPD has the potential to be a neuroprotective substance for cognition dysfunction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 137, March 2018, Pages 249-256
Journal: Brain Research Bulletin - Volume 137, March 2018, Pages 249-256
نویسندگان
Cong Lu, Jingwei Lv, Liming Dong, Ning Jiang, Yan Wang, Bei Fan, Fengzhong Wang, Xinmin Liu,