کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8839101 1613311 2018 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preventing synaptic deficits in Alzheimer's disease by inhibiting tumor necrosis factor alpha signaling
ترجمه فارسی عنوان
جلوگیری از نقص سیناپسی در بیماری آلزایمر با مهار عامل سیگنال آلفا فاکتور نکروز تومور
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
چکیده انگلیسی
The characterization of preclinical stages of Alzheimer's disease (AD) would provide a therapeutic window for prevention. One of the challenges of developing preventive therapy for AD is to identify early biomarkers for intervention studies. We have recently shown that in the TgCRND8 transgenic AD mouse model, increased hippocampal levels of the pro-inflammatory cytokine tumor necrosis factor alpha (TNFα) and enhanced excitatory synaptic transmission were early-onset changes that occurred weeks before amyloid plaque formation. Inhibiting TNFα before plaque formation not only normalized excitatory synaptic function, but also prevented the impairment of synaptic function 4 months later. In this review paper, we will examine the potential contributions of TNFα to the alteration of brain function in preclinical AD. The prospective use of TNFα inhibitors for preventing AD will be discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: IBRO Reports - Volume 4, June 2018, Pages 18-21
نویسندگان
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