کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8920254 1643350 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The relevance of experimental carcinogenicity studies to human safety
ترجمه فارسی عنوان
ارتباط تحقیقات سرطان زایی آزمایشی با ایمنی انسان
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
The two year rodent bioassay has been the standard for carcinogenicity screening for 5 decades. However, numerous examples exist showing that a positive result is not predictive of human cancer risk because of lack of relevant dose and/or mode of action. Utilizing basic principles of carcinogenesis, evaluating chemicals for DNA reactivity, immunosuppression, estrogenic activity and increased cell proliferation provides a more scientific, rationally based process for evaluating risk, in conjunction with metabolism in human cell systems and dose response considerations. George Box once stated, “Models; all are wrong, some are useful.” The two year rodent bioassay screen for carcinogenesis is no longer useful.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Toxicology - Volume 3, April 2017, Pages 6-11
نویسندگان
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