کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8950013 | 1645731 | 2019 | 28 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pharmacokinetics of Oxytetracycline in the Giant Danio (Devario aequipinnatus) following bath immersion
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم آبزیان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Pharmacokinetics of Oxytetracycline in the Giant Danio (Devario aequipinnatus) following bath immersion Pharmacokinetics of Oxytetracycline in the Giant Danio (Devario aequipinnatus) following bath immersion](/preview/png/8950013.png)
چکیده انگلیسی
Oxytetracycline is one of three antimicrobials approved by the United States Food and Drug Administration (FDA) for use in fish aquaculture, but there are few bath pharmacokinetic studies for its use in fish. The objective of this study is to provide data-driven recommendations for the use of oxytetracycline as a bath therapy in the giant danio (Devario aequipinnatus). The pilot study was conducted from 25â¯mg/L to 400â¯mg/L concentration of oxytetracycline in bath. Based on initial pilot study data, a oxytetracycline bath concentration of 400â¯mg/L was used for the final study. At this dose, a maximum plasma concentration (Cmax) for oxytetracycline of 1.31â¯Î¼g/mL was achieved with a half-life of excretion of 13.21â¯h. Water quality parameters for the study included a hardness of <17.1â¯mg/dL, a calcium level of 5.07â¯mg/L, and a magnesium level of 1.17â¯mg/L. Water was buffered using sodium bicarbonate to maintain a pH of between 7.5 and 8.0.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Aquaculture - Volume 498, 1 January 2019, Pages 12-16
Journal: Aquaculture - Volume 498, 1 January 2019, Pages 12-16
نویسندگان
Bryan S. Vorbach, Hardik Chandasana, Hartmut Derendorf, Roy P.E. Yanong,