کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8969312 | 1103196 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Expanding the antigenic repertoire of BCG improves protective efficacy against aerosol Mycobacterium tuberculosis infection
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
We have developed a strain of the tuberculosis vaccine Mycobacterium bovis bacille Calmette Guérin (BCG) that secretes high levels of a fusion protein comprising the immunodominant Mycobacterium tuberculosis Ag85B and ESAT-6 (BCG85B-ES). Mice vaccinated with BCG85B-ES were significantly better protected in the lung against aerosol infection with virulent M. tuberculosis than animals immunized with control BCG. The growth characteristic of BCG85B-ES in host tissue was identical to control BCG, suggesting the improved protective efficacy was directly related to the expression of the Ag85B-ESAT-6 fusion protein. These results suggest that BCG85B-ES warrants further investigation to determine its suitability to control tuberculosis in humans.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 23, Issue 14, 25 February 2005, Pages 1680-1685
Journal: Vaccine - Volume 23, Issue 14, 25 February 2005, Pages 1680-1685
نویسندگان
Umaimainthan Palendira, Joanne M. Spratt, Warwick J. Britton, James A. Triccas,