کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8969771 | 1103294 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Immune response versus mucosal tolerance to mucosally administered antigens
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
The enhancement of protective mucosal responses to infectious agents sought by vaccinologists, and the desired suppression of immune responses to autoantigens, allergens and food antigens induced by mucosal exposure to relevant antigens, may seem paradoxical. However, such outcomes are not mutually exclusive because of a hierarchy in the quality of immune responses: mucosal immunity manifested by the appearance of secretory antibodies and systemic tolerance manifested by diminished cell-mediated responses may be induced concomitantly. We have demonstrated that the ingestion, or nasal application, of a neo-antigen-keyhole limpet hemocyanin (KLH)-primes human volunteers for subsequent humoral mucosal and systemic responses induced by systemic immunization but suppresses cell-mediated responses (T cell proliferation and delayed-type hypersensitivity). Furthermore, extended ingestion of selected food antigens diminished, but did not totally suppress, cell-mediated immunity and levels of serum antibodies while salivary antibodies were easily detectable. Most importantly, the humoral and cellular immune responses induced by systemic immunization with KLH could not be suppressed by subsequent extended ingestion of large doses of the same antigen. Thus, ongoing systemic responses are refractory to the induction of mucosal tolerance in humans. This finding is of considerable importance for the development of and sequence of immunization with mucosally administered vaccines.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 23, Issue 15, 7 March 2005, Pages 1800-1803
Journal: Vaccine - Volume 23, Issue 15, 7 March 2005, Pages 1800-1803
نویسندگان
Jiri Mestecky, Zina Moldoveanu, Charles O. Elson,