کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8994962 | 1114479 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Using Terahertz Pulsed Spectroscopy to Quantify Pharmaceutical Polymorphism and Crystallinity
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Using Terahertz Pulsed Spectroscopy to Quantify Pharmaceutical Polymorphism and Crystallinity Using Terahertz Pulsed Spectroscopy to Quantify Pharmaceutical Polymorphism and Crystallinity](/preview/png/8994962.png)
چکیده انگلیسی
Terahertz pulsed spectroscopy (TPS) is a new technique that is capable of eliciting rich information when investigating pharmaceutical materials. In solids, it probes long-range crystalline lattice vibrations and low energy torsion and hydrogen bonding vibrations. These properties make TPS potentially an ideal tool to investigate crystallinity and polymorphism. In this study four drugs with different solid-state properties were analyzed using TPS and levels of polymorphism and crystallinity were quantified. Carbamazepine and enalapril maleate polymorphs, amorphous, and crystalline indomethacin, and thermotropic liquid crystalline and crystalline fenoprofen calcium mixtures were quantified using partial least-squares analysis. Root-mean-squared errors of cross validation as low as 0.349% and limits of detection as low as approximately 1% were obtained, demonstrating that TPS is an analytical technique of potential in quantifying solid-state properties of pharmaceutical compounds.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 94, Issue 4, April 2005, Pages 837-846
Journal: Journal of Pharmaceutical Sciences - Volume 94, Issue 4, April 2005, Pages 837-846
نویسندگان
Clare J. Strachan, Philip F. Taday, David A. Newnham, Keith C. Gordon, J.Axel Zeitler, Michael Pepper, Thomas Rades,