کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8998183 | 1115607 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of a selective GABAB receptor agonist baclofen on the μ-opioid receptor agonist-induced antinociceptive, emetic and rewarding effects
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
[d-Ala2,N-Me-Phe4,Gly5-ol]enkephalinCGP 35348DVCi.c.v.VTAMPFCintracerebroventricularDMNDAMGO - DREAMi.t. - آی تی.Rewarding effect - اثر پاداشγ-aminobutyric acid - اسید γ-آمینوبوتیریکintrathecal - اینتراکتالBaclofen - باکلوفنEmesis - بی خوابیCNS - دستگاه عصبی مرکزیcentral nervous system - سیستم عصبی مرکزیAntinociception - ضد انعقادFerret - فرت، راسوی اهلی، قاقم اهلیmedial prefrontal cortex - قشر غده پروسترولdorsal vagal complex - مجتمع وگال پشتیventral tegmental area - ناحیه تگمنتوم شکمیDorsal motor nucleus - هسته موتور پشتیGABA - گابا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effect of a selective GABAB receptor agonist baclofen on the μ-opioid receptor agonist-induced antinociceptive, emetic and rewarding effects Effect of a selective GABAB receptor agonist baclofen on the μ-opioid receptor agonist-induced antinociceptive, emetic and rewarding effects](/preview/png/8998183.png)
چکیده انگلیسی
The management of excessive adverse effects of opioids is a major clinical problem. The present study was undertaken to investigate the effect of a selective γ-aminobutyric acid (GABA)B receptor agonist baclofen on the μ-opioid receptor agonist-induced antinociceptive, emetic and rewarding effects. Either morphine or fentanyl produced a dose-dependent antinociceptive effect in both ferrets using Randall-Selitto test and mice using tail-flick test. Under these conditions, pretreatment of baclofen produced an additive antinociception induced by morphine or fentanyl. Furthermore, the augmentation of antinociception induced by systemic administration of baclofen with morphine or fentanyl was completely abolished by either i.c.v. or i.t. pretreatment with the selective GABAB receptor antagonist CGP 35348 in mice. We next investigated the emetic response induced by μ-opioid receptor agonist in ferrets. Morphine at lower doses than that used for antinociceptive assay produced both retching and vomiting, whereas fentanyl failed to produce the retching and vomiting in ferrets. Here we reported for the first time that baclofen significantly suppressed the retching and vomiting induced by morphine, indicating the involvement of GABAB receptor in emetic control pathway. Furthermore, baclofen also inhibited place preference elicited morphine or fentanyl in rats. Taken together, these results suggest that co-administration of baclofen with μ-opioid receptor agonist produced a potentiation of antinociceptive effect, whereas an untoward effect was completely blocked.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 49, Issue 8, December 2005, Pages 1121-1131
Journal: Neuropharmacology - Volume 49, Issue 8, December 2005, Pages 1121-1131
نویسندگان
Tsutomu Suzuki, Arief Nurrochmad, Masahiko Ozaki, Junaidi Khotib, Atsushi Nakamura, Satoshi Imai, Masahiro Shibasaki, Yoshinori Yajima, Minoru Narita,