کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9002080 | 1118571 | 2005 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Prevention of hemorrhagic shock-induced lung injury by heme arginate treatment in rats
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
LPSwet/dryHeme arginateSnMPALASHeme oxygenase-1HSRiNOSIODMPO - DFOMAPK - MAPKδ-aminolevulinate synthase - δ-آمینولولولین سنتازOxidative injury - آسیب اکسیداتیوAcute lung injury - آسیب ریه حادinflammation - التهاب( توروم) Ali - اماintegrated optical density - تراکم نوری یکپارچهtumor necrosis factor-α - تومور نکروز عامل αinducible nitric oxide synthase - سنتاز اکسید نیتریک القاییHemorrhagic shock - شوک هموراژیکTNF-α - فاکتور نکروز توموری آلفاlipopolysaccharide - لیپوپلی ساکاریدcarbon monoxide - منوکسیدکربنmyeloperoxidase - میلوپراکسیداز heme oxygenase - همگام اکسژنازmitogen-activated protein kinase - پروتئین کیناز فعال با mitogen
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Hemorrhagic shock followed by resuscitation (HSR) induces oxidative stress, which leads to acute lung injury. Heme oxygenase (HO)-1 (EC 1.14.99.3), the rate-limiting enzyme in heme catabolism, is inducible by oxidative stress and is thought to play an important role in the protection from oxidative tissue injuries. In this study, we examined expression of HO-1 as well as tissue injuries in the lung, liver, and kidney after HSR in rats. We also pretreated animals with heme arginate (HA), a strong inducer of HO-1, and examined its effect on the HSR-induced lung injury. HO-1 expression significantly increased in the liver and kidney following HSR, while its expression in the lung was very low and unchanged after HSR. In contrast to HO-1 expression, tissue injury and tumor necrosis factor-α (TNF-α) gene expression was more prominent in the lung compared with those in the liver and kidney. HA pretreatment markedly induced HO-1 in pulmonary epithelial cells, and ameliorated the lung injury induced by HSR as judged by the improvement of histological changes, while it decreased TNF-α and inducible nitric oxide synthase gene expression, lung wet weight to dry weight ratio, and myeloperoxidase activity. In contrast, inhibition of HO-1 by tin-mesoporphyrin administration abolished the beneficial effect of HA pretreatment. These findings suggest that tissues with higher HO-1 may be better protected than those with lower HO-1 from oxidative tissue injury induced by HSR. Our findings also indicate that HA pretreatment can significantly suppress the HSR-induced lung injury by virtue of its ability to induce HO-1.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical Pharmacology - Volume 69, Issue 11, 1 June 2005, Pages 1667-1680
Journal: Biochemical Pharmacology - Volume 69, Issue 11, 1 June 2005, Pages 1667-1680
نویسندگان
Kyoichiro Maeshima, Toru Takahashi, Kenji Uehara, Hiroko Shimizu, Emiko Omori, Masataka Yokoyama, Toru Tani, Reiko Akagi, Kiyoshi Morita,