کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9011326 | 1124146 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Analgesic-antiinflammatory properties of Proustia pyrifolia
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کلمات کلیدی
S.E.M.A-549HT-29GMEADRphorbol 12-myristate 13-acetateinfHuman lung carcinomaEthyl etherPGE2HC1DCETLCEt2OtPAIC50LD50Dichloromethane extractXanthine oxidase - زانتین اکسیدازallopurinol - آلوپورینولAnalgesic effect - اثر ضد دردArachidonic acid - اسید آراشیدونیکind - اندرIndomethacin - اندومتاسینlethal dose - دوز مرگبارDichloromethane - دیکلورمتانaqueous extract - عصاره آبMethanol extract - عصاره متانولHexane extract - عصاره هگزinhibitory concentration - غلظت مهاریInfrared - مادون قرمز (فروسرخ)Methanol - متانولMeOH - مونNimesulide - نیمزولیدProstaglandin E2 - پروستاگلاندین E2Column chromatography - کروماتوگرافی ستونthin layer chromatography - کروماتوگرافی لایه نازک
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
The antiinflammatory (per os and topic) and analgesic (per os) properties of the aerial part of Proustia pyrifolia a species in danger of extinction were investigated, and the major compounds of two of its active extracts were isolated. In addition, the evaluation of cytotoxicity in three tumoral cell lines and the acute toxicity of the crude methanol extract were also assayed, together with the antioxidant activity for the different extracts of this species. The results of the evaluation of the topic antiinflammatory activities induced by arachidonic acid, and phorbol 12-myristate 13-acetate of the different extracts showed that this species possesses active constituents that could diminish cyclo-oxygenase and lipoxygenases activities, the enzymes that allow the synthesis of proinflammatory endogenous substances as prostaglandin E2 and leukotrienes, respectively. Our results corroborate the antiinflammatory and analgesic effects of Proustia pyrifolia, and could justify its use in folk medicine for the treatment of rheumatic and gout illnesses. From bio-active extracts β-sitosterol, quercetin and dihydroquercetin were obtained, and these compounds could explain in part the antiinflammatory, analgesic and antioxidant activities of this species. The crude methanol extract did not present acute toxicity or cytotoxic activity, however only this extract exhibited antioxidant activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 99, Issue 1, 13 May 2005, Pages 119-124
Journal: Journal of Ethnopharmacology - Volume 99, Issue 1, 13 May 2005, Pages 119-124
نویسندگان
C. Delporte, N. Backhouse, S. Erazo, R. Negrete, P. Vidal, X. Silva, J.L. López-Pérez, A. San Feliciano, O. Muñoz,