کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9012526 1124934 2005 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Relaxant effects of pravastatin, atorvastatin and cerivastatin on isolated rat aortic rings
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Relaxant effects of pravastatin, atorvastatin and cerivastatin on isolated rat aortic rings
چکیده انگلیسی
Increasing evidence suggests that statins may have pleiotropic effects on vascular wall independent of their cholesterol lowering properties. In the present study, we investigated the acute vascular effects of pravastatin, atorvastatin and cerivastatin on rat isolated aortic rings. Statins effectively and comparably relaxed the aortic rings precontracted submaximally with noradrenaline, in a concentration-dependent manner, in which a high potency was observed with cerivastatin. Endothelium removal or incubation of the aortic rings with nitric oxide synthase inhibitor L-NOARG (10−4 M) and/or cyclooxygenase inhibitor indomethacin (10−5 M) significantly attenuated the acute vasorelaxation induced by either of statin. Additionally, different from the other two statins, a significant reduction was observed in response to cerivastatin in the presence of KATP channel inhibitor, glibenclamide (10−5 M) and Na+- K+ ATPase inhibitor, ouabain (10−4 M). Furthermore, pretreatment of the rings with the cholesterol precursor mevalonate (10−3 M) significantly inhibited the endothelium-mediated relaxant effects of the statins. Our findings suggest that statins could acutely modulate vascular tone importantly by endothelium-dependent and mevalonate-related pathways.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 76, Issue 15, 25 February 2005, Pages 1771-1786
نویسندگان
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