کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9012678 1124998 2005 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Relationships between membrane lipids and ion transport in red blood cells of Dahl rats
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Relationships between membrane lipids and ion transport in red blood cells of Dahl rats
چکیده انگلیسی
Distinct changes of membrane lipid content could contribute to the abnormalities of ion transport that take part in the development of salt hypertension in Dahl rats. The relationships between lipid content and particular ion transport systems were studied in red blood cells (RBC) of Dahl rats kept on low- and high-salt diets for 5 weeks since weaning. Dahl salt-sensitive (SS/Jr) rats on high-salt diet had increased blood pressure, levels of plasma triacylglycerols and total plasma cholesterol compared to salt-resistant (SR/Jr) rats. Furthermore, RBC of SS/Jr rats differed from SR/Jr ones by increased content of total membrane phospholipids, but membrane cholesterol was not changed significantly. SS/Jr rats had higher RBC intracellular Na+ (Nai+) content and enhanced bumetanide-sensitive Rb+ uptake. RBC membrane content of cholesterol and phospholipids correlated positively with RBC Nai+ content, with the activity of Na+-K+ pump and Na+-K+-2Cl− cotransport and also with Rb+ leak. The content of phosphatidylserines plus phosphatidylinositols was positively associated with RBC Nai+ content, with the activity of Na+-K+ pump and Na+-K+-2Cl− cotransport and with Rb+ leak. The content of sphingomyelins was positively related to Na+-K+-2Cl− cotransport activity and negatively to ouabain-sensitive Rb+-K+ exchange. We can conclude that observed relationships between ion transport and the membrane content of cholesterol and/or sphingomyelins, which are known to regulate membrane fluidity, might participate in the pathogenesis of salt hypertension in Dahl rats.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 77, Issue 13, 12 August 2005, Pages 1452-1464
نویسندگان
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