کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9012719 1125004 2005 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
PPAR-γ: A nuclear receptor with affinity for cannabinoids
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
PPAR-γ: A nuclear receptor with affinity for cannabinoids
چکیده انگلیسی
An increasing number of cannabinoid actions are being reported that do not appear to be mediated by either CB1 or CB2, the known cannabinoid receptors. One such example is the synthetic analog ajulemic acid (AJA), which shows potent analgesic and anti-inflammatory effects in rodents and humans. AJA binds weakly to CB1 only at concentrations many fold higher than its therapeutic range, and is, therefore, completely free of psychotropic effects in both normal subjects and pain patients suggesting the involvement of a target site other than CB1. AJA as well as several other cannabinoids appear to have profound effects on cellular lipid metabolism as evidenced by their ability to transform fibroblasts into adipocytes where the accumulation of lipid droplets can be readily observed. Such transformations can be mediated by the activation of the nuclear receptor PPAR-γ. A variety of small molecule ligands including AJA have been shown to induce the activation of PPAR-γ and, in some cases this has led to the introduction of clinically useful agents. It is suggested that PPAR-γ may serve a receptor function for certain actions of some cannabinoids.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 77, Issue 14, 19 August 2005, Pages 1674-1684
نویسندگان
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