کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9015888 | 1127583 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Many good reasons to have STAT3 in the heart
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کلمات کلیدی
ECMSTAT3LIFalpha myosin heavy chainLPSIL-6α-MHCgp130MnSODMAPK - MAPKROS - ROSAngiogenesis - آنژیوژنزIschemia - ایسکمیinterleukin-6 - اینترلوکین ۶Cancer therapy - سرطان درمانmanganese superoxide dismutase - سوپر اکسید دیسموتاز منگنزleukemia inhibitory factor - عامل مهارکننده لوکمیVascular endothelial growth factor - فاکتور رشد اندوتلیال عروقیVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)extra cellular matrix - ماتریس سلولی اضافیsignal transducer and activator of transcription 3 - مبدل سیگنال و فعال کننده رونویسی 3Mouse - موشmitogen activated kinase - میتوکند فعال کینازheart failure - نارسایی قلبیSignal transduction - هدایت سیگنالglycoprotein 130 - گلیکوپروتئین 130Reactive oxidative species - گونه های واکنش پذیر اکسیداتیو
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
The transcription factor signal transducer and activator of transcription 3 (STAT3) participates in a wide variety of physiological processes and directs seemingly contradictory responses, such as proliferation and apoptosis. The constitutive activation of STAT3 promotes tumor growth and angiogenesis and is associated with drug resistance in cancer therapy. In contrast, in the heart, the down-regulation of STAT3 has been associated with end-stage heart failure in patients. Moreover, multiple studies showed that the activation of STAT3 promotes cardiomyocyte survival and hypertrophy, as well as cardiac angiogenesis, in response to various pathophysiologic stimuli, strongly suggesting that STAT3 is beneficial for the heart. Conditional knockout (STAT3-KO) mice harboring a cardiomyocyte-restricted deletion of STAT3 showed enhanced susceptibility to cardiac injury caused by myocardial ischemia, systemic inflammation, or drug toxicity. STAT3-KO mice were also more prone to the pathogenesis of age-related heart failure. Thus, STAT3 is involved in multiple mechanisms required for the protection of the heart from injury and heart failure. These observations should be taken into account in designing novel therapeutic strategies for the prevention of cardiac failure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 107, Issue 1, July 2005, Pages 131-137
Journal: Pharmacology & Therapeutics - Volume 107, Issue 1, July 2005, Pages 131-137
نویسندگان
Denise Hilfiker-Kleiner, Andres Hilfiker, Helmut Drexler,