کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9015927 | 1127597 | 2005 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Modulation of neurotransmitter release by the second messenger-activated protein kinases: Implications for presynaptic plasticity
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کلمات کلیدی
SNARECa2+/calmodulin-dependent kinasePKC (protein kinase C)CKIIPKCCaMKpKaCSPExocytosis - اگزوسیتوزlong-term potentiation - تقویت درازمدتLTP - تقویت طولانی مدت یا LTP RIM - ریمSNAP - ضربه محکم و ناگهانیCysteine string protein - پروتئین رشته سیستینProtein kinase C - پروتئین کیناز سیSynaptic plasticity - پلاستیسیته سیناپسیcasein kinase II - کازئین کیناز II
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
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چکیده انگلیسی
Activity-dependent modulation of synaptic function and structure is emerging as one of the key mechanisms underlying synaptic plasticity. Whereas over the past decade considerable progress has been made in identifying postsynaptic mechanisms for synaptic plasticity, the presynaptic mechanisms involved have remained largely elusive. Recent evidence implicates that second messenger regulation of the protein interactions in synaptic vesicle release machinery is one mechanism by which cellular events modulate synaptic transmission. Thus, identifying protein kinases and their targets in nerve terminals, particularly those functionally regulated by synaptic activity or intracellular [Ca2+], is critical to the elucidation of the molecular mechanisms underlying modulation of neurotransmitter release and presynaptic plasticity. The phosphorylation and dephosphorylation states of synaptic proteins that mediate vesicle exocytosis could regulate the biochemical pathways leading from synaptic vesicle docking to fusion. However, functional evaluation of the activity-dependent phosphorylation events for modulating presynaptic functions still represents a considerable challenge. Here, we present a brief overview of the data on the newly identified candidate targets of the second messenger-activated protein kinases in the presynaptic release machinery and discuss the potential impact of these phosphorylation events in synaptic strength and presynaptic plasticity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 105, Issue 1, January 2005, Pages 69-84
Journal: Pharmacology & Therapeutics - Volume 105, Issue 1, January 2005, Pages 69-84
نویسندگان
A.G. Miriam Leenders, Zu-Hang Sheng,