کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9034296 1132325 2005 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Human embryonic stem cells as a model for nutritional programming: An evaluation
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Human embryonic stem cells as a model for nutritional programming: An evaluation
چکیده انگلیسی
Our laboratory is evaluating whether an epigenetic mechanism involving alterations in DNA methylation can alter the trajectory of embryonic/fetal development in response to maternal nutrients. A similar mechanism may operate in embryo culture environments commonly used in human assisted conception. Since developmental studies on early human embryos in utero are obviously not possible, we have begun to investigate the utility of human embryonic stem cells (hESC) to uncover potential programming mechanisms. This review highlights some of the advantages and problems associated with such a model and suggests that these issues are also broadly applicable to utility of hESC for more general toxicology and drug screening applications.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 20, Issue 3, September–October 2005, Pages 353-367
نویسندگان
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