کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9034657 | 1132631 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Oxidative stress mediates drug-induced hepatotoxicity in rats: a possible role of DNA fragmentation
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کلمات کلیدی
5,5-dithiobis(2-nitrobenzoic acid)MDADICKETCATTBATributyltinGSHTBTALTDTNBddC - DDCROS - ROSAST - آسپارتات ترانس آمینازserum alanine aminotransferase - آلانین آمینوترانسفراز سرمThiobarbituric acid - اسید تیوباربیتوریکDNA fragmentation - تقسیم DNAdiethyldithiocarbamate - دیاتیدیدیتیو کرباماتDiclofenac - دیکلوفناکFree radicals - رادیکال آزادSOD - سدHepatotoxicity - سمیت کبدSuperoxide dismutase - سوکسوکس دیسموتازmalondialdehyde - مالون دی آلدهیدLipid peroxidation - پراکسیداسیون لیپیدCatalase - کاتالازreduced glutathione - کاهش گلوتاتیونIntracellular calcium - کلسیم داخل سلولیReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Oxidative stress mediates drug-induced hepatotoxicity in rats: a possible role of DNA fragmentation Oxidative stress mediates drug-induced hepatotoxicity in rats: a possible role of DNA fragmentation](/preview/png/9034657.png)
چکیده انگلیسی
Sodium diethyldithiocarbamate, diclofenac and ketoconazol are three important chemotherapeutic agents that are commonly associated with hepatotoxicity. This study was undertaken to provide a better understanding of the mechanism through which these drugs induce hepatotoxicity. Some of the possible mechanisms underlying such modulation were investigated. The hepatotoxic activity of sodium diethyldithiocarbamate (800 mg kgâ1); diclofenac (200 mg kgâ1) and ketoconazol (100 mg kgâ1) were investigated in vivo through the assessment of liver functions, lipid peroxidation and histopathological examination. It was found that all drugs have induced severe hepatic damage as evidenced by the elevation serum aminotransferase activities and confirmed by histological changes of liver. In addition, the drug-induced hepatotoxicity was also associated with massive liver DNA fragmentation and an increase in lipid peroxidation. These results strongly suggest a positive correlation between hepatotoxicity and DNA fragmentation. Moreover, this study also implicates calcium as a potential mediator of the drug-induced oxidative stress associated with hepatotoxicity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology - Volume 208, Issue 3, 30 March 2005, Pages 367-375
Journal: Toxicology - Volume 208, Issue 3, 30 March 2005, Pages 367-375
نویسندگان
Amr Amin, Alaa A. Hamza,