Névralgie du trijumeau sous traitement anti-angiogénique : effet secondaire du bévacizumab ?

A 68 years old patient, with a lung adenocarcinoma, and platin chemotherapy, anti-VEGF therapy for 2 months, begins a V1 bilateral trigeminal neuralgia. The trigeminal neuralgia stops 4 months after the end of antiangiogenic therapy. One month after the end of bevacizumab after 10 months of using, he suffers of colon perforation. A lot of questions are asked: what about the classical and symptomatic trigeminal neuralgia? What about the mechanism of nasal perforation and bowel perforation in antiangiogenic adverse effect? What is the hypothesis about the relationship between trigeminal neuralgia and antiangiogenic drug?