کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9131961 | 1160973 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Molecular cytogenetics discards polyploidy in mammals
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
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چکیده انگلیسی
Polyploidy, the presence of more than two chromosome sets, is common in plants, but extremely rare in animals. The absence of polyploid organisms with well-differentiated sex chromosomes suggests that the disruption of the dosage between autosomes and sex chromosomes is incompatible with normal development. Thus, the announcement in 1999 of tetraploidy in a mammal, the South American red vizcacha rat Tympanoctomys barrerae, provoked great interest, even though the definitive proof of tetraploidy, the presence of four copies of each chromosome, was never provided. Here we used classical and molecular cytogenetics to test the ploidy level of T. barrerae and demonstrate that only two copies of each chromosome are present in this karyotype. The red vizcacha rat is clearly diploid and the amplification and dispersion of repetitive sequences best explain the large genome size of this mammal. Thus, polyploidy in mammals remains as unlikely as it has always been.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Genomics - Volume 85, Issue 4, April 2005, Pages 425-430
Journal: Genomics - Volume 85, Issue 4, April 2005, Pages 425-430
نویسندگان
Marta Svartman, Gary Stone, Roscoe Stanyon,