کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9131967 | 1160973 | 2005 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Distinct expression profiles of Mecp2 transcripts with different lengths of 3â²UTR in the brain and visceral organs during mouse development
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Distinct expression profiles of Mecp2 transcripts with different lengths of 3â²UTR in the brain and visceral organs during mouse development Distinct expression profiles of Mecp2 transcripts with different lengths of 3â²UTR in the brain and visceral organs during mouse development](/preview/png/9131967.png)
چکیده انگلیسی
Four different transcripts of the Mecp2 gene can be distinguished by the length of the 3â² untranslated region generated by usage of alternative polyadenylation sites. In situ hybridization analyses encompassing embryonic to 20-week postnatal age showed that transcripts are expressed in the central nervous system, with a progressive restriction during development culminating in localized strong expression in the cerebral cortex, olfactory bulb, hippocampal formation, and internal granule and Purkinje layer of the cerebellum. Real-time RT-PCR measurements of Mecp2 transcript levels showed variations with mouse age in two distinctive patterns that are unique to the central nervous system and the visceral organs, respectively. The 10-kb mRNA is the predominant form expressed in the brain in contrast to the shorter species expressed in the lung and liver. The developmental profile of Mecp2 mRNA highlights a potential tissue-specific function of the 3â²UTR in the regulation of MeCP2 protein synthesis in response to the age-specific requirement of MeCP2 function during the life of the mouse.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Genomics - Volume 85, Issue 4, April 2005, Pages 441-452
Journal: Genomics - Volume 85, Issue 4, April 2005, Pages 441-452
نویسندگان
Gregory J. Pelka, Catherine M. Watson, John Christodoulou, Patrick P.L. Tam,