کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9132063 | 1160983 | 2005 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Stage-dependent gene expression profiles during natural killer cell development
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Stage-dependent gene expression profiles during natural killer cell development Stage-dependent gene expression profiles during natural killer cell development](/preview/png/9132063.png)
چکیده انگلیسی
Natural killer (NK) cells develop from hematopoietic stem cells (HSCs) in the bone marrow. To understand the molecular regulation of NK cell development, serial analysis of gene expression (SAGE) was applied to HSCs, NK precursor (pNK) cells, and mature NK cells (mNK) cultured without or with OP9 stromal cells. From 170,464 total individual tags from four SAGE libraries, 35,385 unique genes were identified. A set of genes was expressed in a stage-specific manner: 15 genes in HSCs, 30 genes in pNK cells, and 27 genes in mNK cells. Among them, lipoprotein lipase induced NK cell maturation and cytotoxic activity. Identification of genome-wide profiles of gene expression in different stages of NK cell development affords us a fundamental basis for defining the molecular network during NK cell development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Genomics - Volume 86, Issue 5, November 2005, Pages 551-565
Journal: Genomics - Volume 86, Issue 5, November 2005, Pages 551-565
نویسندگان
Hyung-Sik Kang, Eun-Mi Kim, Sanggyu Lee, Suk-Ran Yoon, Toshihiko Kawamura, Young-Cheol Lee, Sangsoo Kim, Pyung-Keun Myung, San Ming Wang, Inpyo Choi,