کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
913916 | 918372 | 2012 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evoked bursting in injured Aβ dorsal root ganglion neurons: A mechanism underlying tactile allodynia
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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![عکس صفحه اول مقاله: Evoked bursting in injured Aβ dorsal root ganglion neurons: A mechanism underlying tactile allodynia Evoked bursting in injured Aβ dorsal root ganglion neurons: A mechanism underlying tactile allodynia](/preview/png/913916.png)
چکیده انگلیسی
Chronic compression of rat dorsal root ganglion (CCD) produced tactile allodynia accompanied with hyperexcitability of the myelinated Aβ dorsal root ganglion (DRG) neurons. The Aβ DRG neuron hyperexcitability exhibits as bursting discharges in response to peripherally evoked action potentials (evoked bursting [EB]). The incidence of EB was significantly increased after chronic compression of DRG (CCD) (43.3%) vs control (13.3%). EB was maintained by oscillation of the membrane potential, and its duration was increased when the membrane potential was depolarized. EB was found to coexist in some neurons with spontaneous bursting (SB), but EB always occurred at a more negative membrane potential than SB. Afterdischarges of the wide dynamic range neurons of the dorsal horn in the spinal cord in response to electrical stimulation of Aβ afferent nerve fibers were suppressed by blocking EB of the DRG neurons. CCD neurons with EB exhibited increased current density of persistent sodium current (INap) and hyperpolarization-activated cation current (Ih) and decreased α-dendrotoxin (α-DTX) sensitive current (IDTX). The increased Ih activated by afterhyperpolarization of peripheral afferent action potential was necessary for EB generation and a balance between IDTX and INap might be necessary for EB maintenance. This study may suggest a role of EB of myelinated DRG neurons in development of allodynia after nerve injury and a potential pharmaceutical therapy in treating neuropathic allodynia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: PAIN - Volume 153, Issue 3, March 2012, Pages 657-665
Journal: PAIN - Volume 153, Issue 3, March 2012, Pages 657-665
نویسندگان
Ying Song, Hui-Ming Li, Rou-Gang Xie, Zhi-Feng Yue, Xue-Jun Song, San-Jue Hu, Jun-Ling Xing,