کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
914056 918382 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Treatment of Nav1.7-mediated pain in inherited erythromelalgia using a novel sodium channel blocker
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Treatment of Nav1.7-mediated pain in inherited erythromelalgia using a novel sodium channel blocker
چکیده انگلیسی
Mutations in the SCN9A gene leading to deficiency of its protein product, Nav1.7, cause congenital indifference to pain (CIP). CIP is characterized by the absence of the ability to sense pain associated with noxious stimuli. In contrast, the opposite phenotype to CIP, inherited erythromelalgia (IEM), is a disorder of spontaneous pain caused by missense mutations resulting in gain-of-function in Nav1.7 that promote neuronal hyperexcitability. The primary aim of this study was to demonstrate that Nav1.7 antagonism could alleviate the pain of IEM, thereby demonstrating the utility of this opposite phenotype model as a tool for rapid proof-of-concept for novel analgesics. An exploratory, randomized, double-blind, 2-period crossover study was conducted in 4 SCN9A mutation-proven IEM patients. In each treatment period (2 days), separated by a 2-day washout period, patients were orally administered XEN402 (400 mg twice daily) or matching placebo. In 3 patients, pain was induced by heat or exercise during each treatment arm. A fourth patient, in constant severe pain, required no induction. Patient-reported outcomes of pain intensity and/or relief were recorded, and the time taken to induce pain was measured. The ability to induce pain in IEM patients was significantly attenuated by XEN402 compared with placebo. XEN402 increased the time to maximal pain induction and significantly reduced the amount of pain (42% less) after induction (P = .014). This pilot study showed that XEN402 blocks Nav1.7-mediated pain associated with IEM, thereby demonstrating target engagement in humans and underscoring the use of rare genetic disorders with mutant target channels as a novel approach to rapid proof-of-concept.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: PAIN - Volume 153, Issue 1, January 2012, Pages 80-85
نویسندگان
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