کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
914703 | 918413 | 2009 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Unravelling the relationship between age, nociception and joint destruction in naturally occurring osteoarthritis of Dunkin Hartley guinea pigs
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
Osteoarthritis (OA) is a debilitating and painful disease, the incidence of which increases with advancing age. One of the confounding aspects of OA is that there is a disconnect between the severity of joint degeneration and the intensity of pain reported. This study examined the relationship between age, joint nociception, and joint pathology in an animal model of naturally occurring OA. Dunkin Hartley guinea pigs were grouped according to age: young (2-5Â months) and senescent (17-37Â months). Joint nociception was objectively measured in these animals by recording electrophysiologically from knee joint primary afferents in response to non-noxious and noxious movements of the knee. Joint pathology in the same knees was then determined by histomorphology and micro-computerized tomography (micro-CT). A principal components analysis was carried out on the data to determine if any correlation exists between each of the measured variables. In aged guinea pigs, 33% of joint mechanosensory nerves were spontaneously active, whereas young animals showed no such neural activity at rest. The frequency of afferent firing evoked by noxious movements was greater in old guinea pigs. Micro-CT and histopathological determination of OA positively correlated with age; however, there was no significant correlation between the severity of joint degeneration and nociception. In the Dunkin Hartley model of inveterate OA, the level of joint pathology correlates well with increasing age. This study also provides the first objective evidence that there is no correlation between joint nociception and articular damage, thereby corroborating the clinical observation that pain is a poor predictor of OA severity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: PAIN - Volume 141, Issue 3, February 2009, Pages 222-232
Journal: PAIN - Volume 141, Issue 3, February 2009, Pages 222-232
نویسندگان
Jason J. McDougall, Benjamin Andruski, Niklas Schuelert, Benedikt HallgrÃmsson, John R. Matyas,