کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
914996 | 918426 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Correlation of epidermal nerve fiber density with pain-related evoked potentials in HIV neuropathy
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کلمات کلیدی
NCVPrEPSNCHAARTDDINDSNSSSkin biopsy - بیوپسی پوستIntraepidermal nerve fiber density - تراکم فیبر داخل عضلانیdidanosine - دی دی آمینnerve conduction velocity - سرعت هدایت عصبSNAP - ضربه محکم و ناگهانیSmall-fiber neuropathy - نوروپاتی کوچک فیبرhuman immunodeficiency virus - ویروس نقص ایمنی انسانیHIV - ویروس نقص ایمنی انسانی Sensory nerve action potential - پتانسیل عمل عصب احساسیPain-related evoked potentials - پتانسیل های ناشی از درد مرتبط است
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
HIV associated sensory neuropathy is a common neurological disorder with reported prevalence of 53%. When only small fibers are involved, the diagnosis of neuropathy remains difficult since standard nerve conduction studies generally are unremarkable. We assessed a method to identify small-fiber neuropathy using electrically evoked pain-related potentials and correlated the electrophysiological results with intraepidermal nerve fiber density in patients with HIV associated sensory neuropathy. Nineteen HIV positive patients were investigated for clinically diagnosed peripheral neuropathy with Neuropathy Symptoms Score (NSS) ⩾ 3 and Neuropathy Disability Score (NDS) ⩾ 5. Nine healthy HIV negative control subjects were recruited. We performed standard nerve conduction testing, electrically evoked pain-related potentials and skin biopsy in all participants. Pain-related evoked potentials revealed abnormalities in all HIV positive neuropathy patients, while standard nerve conduction testing was abnormal in eight patients only. Pain-related evoked potential latencies and amplitudes strongly correlated with intraepidermal nerve fiber density. The method of pain-related evoked potential conduction appears to be a sensitive, fast, non-invasive technique for the detection of small-fiber neuropathy and may prove to become a valuable diagnostic asset.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: PAIN - Volume 138, Issue 1, 15 August 2008, Pages 79-86
Journal: PAIN - Volume 138, Issue 1, 15 August 2008, Pages 79-86
نویسندگان
Mark Obermann, Zaza Katsarava, Stefan Esser, Claudia Sommer, Lan He, Laura Selter, Min-Suk Yoon, Holger Kaube, Hans-Christoph Diener, Matthias Maschke,