کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
914998 918426 2008 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Spinal brain-derived neurotrophic factor governs neuroplasticity and recovery from cold-hypersensitivity following dorsal rhizotomy
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Spinal brain-derived neurotrophic factor governs neuroplasticity and recovery from cold-hypersensitivity following dorsal rhizotomy
چکیده انگلیسی
Brain-derived neurotrophic factor (BDNF) has multiple effects on tropomyosin-related receptor kinase B - (TrkB) expressing neurons, including potentiation of spinal nociceptive transmission and stimulation of axon outgrowth. BDNF is upregulated in the spinal cord following dorsal root injury (DRI), a manipulation which elicits both pain and collateral sprouting. Transection of the C7 and C8 dorsal roots (C7/8 DRI) generates cold pain in the ipsilateral forepaw which peaks at 10 days, and resolves within three weeks after injury. In the present study, we investigated the influence of chronic BDNF sequestration, by intrathecal delivery of TrkB-Fc, on the plasticity of nociceptive circuitry and resultant cold pain behaviour following spinal deafferentation. C7/8 DRI resulted in a pronounced deafferentation of the C7 dorsal horn and significant depletion of both peptidergic- and non-peptidergic nociceptive projections. While changes in GAP-43 expression revealed that endogenous BDNF was exerting an overall plasticity-promoting influence on intraspinal axons after DRI, continuous TrkB-Fc treatment stimulated sprouting of nociceptive terminals. DRI stimulated a BDNF-dependent increase in the density of GABAergic interneuronal processes, as indicated by increased vesicular GABA transporter - (VGAT) and neuropeptide Y - (NPY) positive terminal densities. Finally, chronic TrkB-Fc treatment prevented cold pain resolution. These findings demonstrate that endogenous BDNF has both plasticity-promoting and plasticity-suppressing effects on the intrinsic spinal components of nociceptive circuitry, which are likely to underlie cold pain behaviour following C7/8 DRI.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: PAIN - Volume 138, Issue 1, 15 August 2008, Pages 98-110
نویسندگان
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