کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
915081 918430 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Selective inhibition from the anterior hypothalamus of C- versus A-fibre mediated spinal nociception
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Selective inhibition from the anterior hypothalamus of C- versus A-fibre mediated spinal nociception
چکیده انگلیسی
Modulation of spinal nociception from the anterior hypothalamus/preoptic area (AH/POA), and consequent alterations in the pain experience may contribute to integrated responses brought into play during fear or stress and as part of the sickness response. This study was designed to compare the effects of descending control from AH/POA on A- versus C-fibre-evoked spinal nociception, since any differential control is of behavioural and clinical importance given that A-fibre and C-fibre nociceptors convey different qualities of the pain signal (first and second pain, respectively), and play different roles in the development and maintenance of chronic pain states. In anaesthetised rats, electromyographic responses were recorded to monitor thresholds of withdrawal to slow (2.5 °C s−1) or fast (7.5 °C s−1) rates of skin heating of the hindpaw, to preferentially activate C- or A-nociceptors, respectively. Neuronal activation by microinjection of dl-homocysteic acid at sites within a specific region of AH/POA, lateral area of the anterior hypothalamus (LAAH), significantly increased response thresholds to slow heating rates (p < 0.02, n = 11), but not those to fast rates of heating (p = 0.48, n = 10). Injection of DLH adjacent to LAAH (n = 9) had no significant effect on responses to slow (n = 8) or fast (n = 9) rates of skin heating. The functional significance of differential descending control of spinal processing of C- and A-nociceptive inputs is discussed with respect to roles both of the LAAH in pain processing, and of C- and A-nociceptive inputs in acute and chronic pain.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: PAIN - Volume 136, Issue 3, 15 June 2008, Pages 305-312
نویسندگان
, , ,