کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
915550 1473257 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Analgesic action of gabapentin on chronic pain in the masticatory muscles: A randomized controlled trial
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Analgesic action of gabapentin on chronic pain in the masticatory muscles: A randomized controlled trial
چکیده انگلیسی

Chronic masticatory myalgia (CMM) can be defined as constant pain in the masticatory muscles for more than 6 months and is influenced by the central nervous system. The antiepileptic agent gabapentin acts centrally and is used for managing different types of chronic pain conditions. The objective of this study was to evaluate the analgesic action of gabapentin on CMM. In this 12-week randomized controlled clinical trial 50 patients were randomly allocated into two study groups: 25 received gabapentin and 25 received placebo. The outcome measures utilized were pain reported on a VAS (VAS-pain), Palpation Index (PI) and impact of CMM on daily functioning reported on a VAS (VAS-function). Thirty-six patients completed the study. Gabapentin showed to be clinically and statistically superior to placebo in reducing pain reported by patients (gabapentin = 51.04%; placebo = 24.30%; P = 0.037), masticatory muscle hyperalgesia (gabapentin = 67.03%; placebo = 14.37%; P = 0.001) and impact of CMM on daily functioning (gabapentin = 57.70%; placebo = 16.92%; P = 0.022). It can be concluded from this study that gabapentin is effective for the management of CMM.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pain - Volume 127, Issues 1–2, January 2007, Pages 151–160
نویسندگان
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