کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
923211 | 921074 | 2008 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Aspirin, but not propranolol, attenuates the acute stress-induced increase in circulating levels of interleukin-6: A randomized, double-blind, placebo-controlled study Aspirin, but not propranolol, attenuates the acute stress-induced increase in circulating levels of interleukin-6: A randomized, double-blind, placebo-controlled study](/preview/png/923211.png)
Psychosocial stress might increase the risk of atherothrombotic events by setting off an elevation in circulating levels of the proinflammatory cytokine interleukin (IL)-6. We investigated the effect of aspirin and propranolol on the responsiveness of plasma IL-6 levels to acute psychosocial stress. For 5 days, 64 healthy subjects were randomized, double-blind, to daily oral aspirin 100 mg plus long-acting propranolol 80 mg, aspirin 100 mg plus placebo, long-acting propranolol 80 mg plus placebo, or placebo plus placebo. Thereafter, all subjects underwent the 13-min Trier Social Stress Test, which combines a preparation phase, a job interview, and a mental arithmetic task. Plasma IL-6 levels were measured in blood samples collected immediately pre- and post-stress, and 45 min and 105 min thereafter. The change in IL-6 from pre-stress to 105 min post-stress differed between subjects with aspirin medication and those without (p = 0.033; ηp2 = 0.059). IL-6 levels increased less from pre-stress to 105 min post-stress (p < 0.027) and were lower (p = 0.010) at 105 min post-stress in subjects with aspirin than in subjects without aspirin. The significance of these results was maintained when controlling for gender, age, waist-to-hip ratio, mean arterial blood pressure, and smoking status. Medication with propranolol was not significantly associated with the stress-induced change in IL-6 levels. Also, aspirin and propranolol did not significantly interact in determining the IL-6 stress response. Aspirin but not propranolol attenuated the stress-induced increase in plasma IL-6 levels. This suggests one mechanism by which aspirin treatment might reduce the risk of atherothrombotic events triggered by acute mental stress.
Journal: Brain, Behavior, and Immunity - Volume 22, Issue 2, February 2008, Pages 150–157