کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9236731 | 1207488 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chemokine receptors support infiltration of lymphocyte subpopulations in human hepatocellular carcinoma
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کلمات کلیدی
PBLNKTNILTIL - بهTumor-infiltrating lymphocytes - تومور لنفوسیتها نفوذ می کندnatural killer T cells - سلول های T قاتل طبیعیNatural killer cells - سلولهای کشنده طبیعیLymphocyte - لنفوسیتperipheral blood lymphocytes - لنفوسیت های خون محیطیHepatocellular carcinoma - کارسینوم هپاتوسلولار(کارسینوم سلولهای استخوانی)chemokine receptor - گیرنده شیمیایی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Chemokine receptors support infiltration of lymphocyte subpopulations in human hepatocellular carcinoma Chemokine receptors support infiltration of lymphocyte subpopulations in human hepatocellular carcinoma](/preview/png/9236731.png)
چکیده انگلیسی
The presence of lymphocyte infiltration in human hepatocellular carcinoma (HCC) is evident. However, immune regulation of lymphocytes in HCC is poorly characterized. In this study, we investigated the chemokine receptor and memory, activation and adhesion markers of major leukocyte subsets present in tumor, nontumor liver, and peripheral blood. T cells from both tumor and peritumor liver displayed high levels of activation and homing markers. CCR5 and CXCR3 were expressed in a large proportion of CD45RO+, CD69+, CD27+, and CD11a+ T cells from tumor compared with T cells from circulation. The proportion of CCR6- and CXCR3-expressing natural killer cells (NK) and natural killer T cells (NKT) was significantly increased in the tumor and nontumor liver compared with peripheral blood. This study demonstrates the role of chemokine receptors in the recruitment of specific lymphocyte subsets to the liver in HCC and suggests the importance of these receptors in regulation of immune defense against HCC.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 114, Issue 2, February 2005, Pages 174-182
Journal: Clinical Immunology - Volume 114, Issue 2, February 2005, Pages 174-182
نویسندگان
Yuqing Liu, Ronnie T. Poon, Jeremy Hughes, Xiaoqin Feng, Wan Ching Yu, Sheung Tat Fan,