کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
923786 | 921127 | 2006 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Identifying immune traits and biobehavioral correlates: Generalizability and reliability of immune responses in rhesus macaques
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Identifying immune traits and biobehavioral correlates: Generalizability and reliability of immune responses in rhesus macaques Identifying immune traits and biobehavioral correlates: Generalizability and reliability of immune responses in rhesus macaques](/preview/png/923786.png)
چکیده انگلیسی
Variation in immune responses over time and in different contexts presents a methodological challenge for characterizing the typical immune status of an individual. Our analyses statistically evaluated sampling strategies for optimizing the determination of an “immune trait” in studies of individual differences with nonhuman primates. Lymphocyte proliferation and natural killer cell activity were assessed on multiple occasions at 3-week intervals in male rhesus macaques for up to 1 year while they lived in undisturbed conditions. Generalizability and Monte Carlo analyses were utilized to explore the benefits of multiple evaluations and the effects of reliability on replication. There were substantial gains in reliability and stability by obtaining 4 or more immune assessments of the same individual, and the benefits continued to accrue to an optimal assessment level of 10 or more evaluations for each individual. The value of determining “immune traits” was then exemplified by demonstrating the degree to which the monkeys' handedness correlated with reliable indices of proliferative and cytolytic responses averaged over 1 year of assessment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain, Behavior, and Immunity - Volume 20, Issue 4, July 2006, Pages 349-358
Journal: Brain, Behavior, and Immunity - Volume 20, Issue 4, July 2006, Pages 349-358
نویسندگان
Suzanne C. Segerstrom, Gabriele R. Lubach, Christopher L. Coe,