کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9262896 1215811 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
DM and DO shape the repertoire of peptide-MHC-class-II complexes
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
DM and DO shape the repertoire of peptide-MHC-class-II complexes
چکیده انگلیسی
The presentation of antigenic peptides by MHC class II molecules is essential for activation of CD4+ T cells. The formation of most peptide-MHC-class-II complexes is influenced by the actions of two specialized accessory proteins - DM and DO - located in the endosomal/lysosomal system where peptide loading occurs. DM removes class-II-associated invariant-chain peptide (CLIP) from newly synthesized class II molecules, but by now it is clearly established that this is only a special case of the general peptide-editing function of DM. Recent data have begun to explain the molecular basis for the editing activity. The other accessory protein, DO, modulates DM activity in vitro, but the physiological importance of DO is unclear. New evidence from several laboratories has provided clues that may soon change this.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Immunology - Volume 17, Issue 1, February 2005, Pages 65-70
نویسندگان
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