کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9266226 | 1217274 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Interleukin-17 enhances bFGF-, HGF- and VEGF-induced growth of vascular endothelial cells
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کلمات کلیدی
bFGFFCSHGFCTLAENA-78cytotoxic T lymphocyte associated antigenAngiogenesis - آنژیوژنزinterleukin - اینترلوکینinterleukin-17 - اینترلوکین 17fetal calf serum - سرم گوساله جنینVascular endothelial cells - سلولهای اندوتلیال عروقیHepatocyte growth factor - عامل رشد هپاتوسیتVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)Vascular endothelial cell growth factor - فاکتور رشد سلول اندوتلیال عروقیbasic fibroblast growth factor - فاکتور رشد فیبروبلاست پایه
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Interleukin-17 (IL-17) is a CD4 T cell-derived proinflammatry and proangiogenic cytokine. In this study, we investigated the effects of this cytokine on vascular endothelial cell growth induced by a well-known direct angiogenic factor bFGF, HGF, VEGF, CXCL5/ENA-78 or CXCL8/IL-8. While a wide range of doses of IL-17 alone did not show the ability to stimulate the growth of human dermal microvascular endothelial cells (HMVECs), bFGF, HGF, VEGF, CXCL5 or CXCL8 significantly induced the growth of HMVECs in vitro. When bFGF and IL-17 were used in combination, 10 or 100Â ng/ml IL-17 enhanced 10Â ng/ml bFGF-induced growth of HMVECs. Similarly, when HGF and IL-17 were combined together, 10 or 100Â ng/ml IL-17 potentiated 10Â ng/ml HGF-induced growth of HMVECs. When VEGF and IL-17 were used together, 10Â ng/ml IL-17 did not significantly enhance 10Â ng/ml VEGF-induced growth, whereas 100Â ng/ml IL-17 clearly promoted 10Â ng/ml VEGF-mediated proliferation of HMVECs. On the contrary, IL-17 did not augment CXCL5- and CXCL8-mediated growth. These results indicate that IL-17 itself does not have the capability to stimulate the growth of vascular endothelial cells, whereas IL-17 is able to selectively enhance the mitogenic activity of bFGF, HGF, and VEGF for vascular endothelial cells. Our findings also suggest that IL-17 may promote bFGF-, HGF- and VEGF-meadiated angiogenesis through enhancing bFGF-, HGF- and VEGF-induced growth of vascular endothelial cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunology Letters - Volume 98, Issue 2, 15 May 2005, Pages 189-193
Journal: Immunology Letters - Volume 98, Issue 2, 15 May 2005, Pages 189-193
نویسندگان
Hidenori Takahashi, Muneo Numasaki, Michael T. Lotze, Hidetada Sasaki,