کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9266462 | 1217287 | 2005 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Post-translational control of chemokines: a role for decoy receptors?
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کلمات کلیدی
MMPCXCRLPSDuffy Antigen Receptor for ChemokinesHHV-8CXCLCCRECMCCLGPCRGAGG-protein-coupled receptor - G-پروتئین گیرندهADAM - آدامAntagonists - آنتاگونیست هاa disintegrin and metalloproteinase - تخریب و متالوپروتئینازDARC - دارسیEndothelial cell - سلول های اندوتلیالlipopolysaccharide - لیپوپلی ساکاریدCXC chemokine ligand - لیگاند شیمیایی CXCCC chemokine ligand - لیگاند کیموکین CCextra-cellular matrix - ماتریکس خارج سلولیmatrix metalloproteinase - ماتریکس متالوپروتئینازLeukocyte migration - مهاجرت لکوسیتHuman herpesvirus-8 - ویروس هرویین انسانی 8Proteases - پروتئازChemokines - کرموین هاGlycosaminoglycan - گلیکوزآمینوگلیکانCXC chemokine receptor - گیرنده شیمیایی CXCDecoy receptor - گیرنده طعمهCC chemokine receptor - گیرنده کیموکین CC
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
It is well-established that chemokines play a critical role in the orchestration of inflammation and immunity. Interactions between chemokines and their receptors are essential for the homing of specific subsets of leukocytes to their functional microenvironments. They also influence other diverse biological processes such as development, leukocyte activation, Th1/Th2 polarisation, tumour metastasis, angiogenesis, and HIV pathogenesis. However, despite their importance, only now are we beginning to understand the complex regulation brought to bear on these molecules. In this review, we discuss a number of these key chemokine regulators that exert their influence once these proteins have been synthesised. We examine (i) chemokine storage, release, and presentation, (ii) protease regulation, (iii) viral manipulation of host chemokines, and (iv) natural mammalian receptor antagonists. Principally, the growing evidence for a role for decoy receptors in the chemokine system is discussed. In particular, the potential decoy function of the 'silent' pro-inflammatory chemokine receptor D6 is described alongside two other candidate decoy receptor molecules, DARC, and CCX-CKR. Dissecting the biological and pathological function of these chemokine controllers will lead to a deeper understanding of chemokine regulation, and may reveal novel strategies to therapeutically modify the chemokine system.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunology Letters - Volume 96, Issue 2, 31 January 2005, Pages 163-174
Journal: Immunology Letters - Volume 96, Issue 2, 31 January 2005, Pages 163-174
نویسندگان
Iain Comerford, Robert J.B. Nibbs,