کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9276036 | 1222378 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Activity of cefepime and carbapenems in experimental pneumonia caused by porin-deficient Klebsiella pneumoniae producing FOX-5 β-lactamase
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروب شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The in-vivo activities of cefepime, imipenem and meropenem against the porin-deficient strain Klebsiella pneumoniae C2 and its derivative K. pneumoniae C2(pMG252) coding for the AmpC-type β-lactamase FOX-5 were determined. Bactericidal activities were determined with the kill-curve method. A pneumonia model in guineapigs was developed, and Cmax, t½ and ÎT/MIC were calculated for the three agents tested. Animals were treated for 72 h with sterile saline (control group) or with cefepime, imipenem or meropenem (240 mg/kg/day, intramuscularly, three times daily). Bacterial counts in lungs (log10 CFU/g tissue) were determined by serial dilution. MICs (mg/L) of cefepime, imipenem and meropenem against K. pneumoniae C2/K. pneumoniae C2(pMG252), determined by macrodilution, were: 0.5/4, 0.5/0.5 and 0.25/0.5, respectively. Bacterial counts in the lungs of animals infected with K. pneumoniae C2 and treated with antimicrobial agents were always lower than in the control group (cefepime, 4.4 ± 0.5; imipenem, 4.6 ± 0.4; meropenem, 4.7 ± 0.5; control group, 5.6 ± 0.8; p < 0.01). No significant differences were observed among the groups receiving therapy (p > 0.05). Bacterial lung clearance was higher in treated animals than in control animals following infection with K. pneumoniae C2(pMG252) (cefepime, 4.5 ± 0.4; imipenem, 4.0 ± 0.3; meropenem, 4.6 ± 0.4; control group, 6.1 ± 0.6; p < 0.01), with imipenem producing better clearance than either cefepime or meropenem (p < 0.05). Thus, in the guinea-pig pneumonia model, cefepime, imipenem and meropenem were each effective against the porin-deficient K. pneumoniae strain C2 and its derivative expressing the plasmid-mediated AmpC type β-lactamase FOX-5.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Microbiology and Infection - Volume 11, Issue 1, January 2005, Pages 31-38
Journal: Clinical Microbiology and Infection - Volume 11, Issue 1, January 2005, Pages 31-38
نویسندگان
C. Pichardo, M. del Carmen Conejo, M. Bernabéu-Wittel, A. Pascual, M.E. Jiménez-MejÃas, M. de Cueto, M.E. Pachón-Ibáñez, I. GarcÃa, J. Pachón, L. MartÃnez-MartÃnez,