کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9277965 | 1593090 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Homology, disruption and phenotypic analysis of CaGS Candida albicans gene induced during macrophage infection
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Homology, disruption and phenotypic analysis of CaGS Candida albicans gene induced during macrophage infection Homology, disruption and phenotypic analysis of CaGS Candida albicans gene induced during macrophage infection](/preview/png/9277965.png)
چکیده انگلیسی
During macrophage infection Candida albicans expresses differentially several genes whose functions are associated with its survival strategy. Among others, we have isolated CaGS gene, which is homologous to SNF3, a glucose sensor of Saccharomyces cerevisiae. To elucidate its potential role during infection, CaGS has been disrupted and the resulting phenotype analyzed on different solid media. The null mutant lost the ability to form hyphae on a medium with low glucose concentration and serum. Furthermore, this mutant does not disrupt macrophage in in vitro infections. We believe that this putative glucose sensor is involved in hyphal development during macrophage infection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEMS Immunology and Medical Microbiology - Volume 45, Issue 3, 1 September 2005, Pages 471-478
Journal: FEMS Immunology and Medical Microbiology - Volume 45, Issue 3, 1 September 2005, Pages 471-478
نویسندگان
Marina Luongo, Amalia Porta, Bruno Maresca,