کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9277990 1222824 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The Shigella flexneri serotype Y vaccine candidate SFL124 originated from a serotype 2a background
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
The Shigella flexneri serotype Y vaccine candidate SFL124 originated from a serotype 2a background
چکیده انگلیسی
Shigella flexneri is endemic in most developing countries and responsible for the highest mortality rate among the Shigella species. The attenuated serotype Y S. flexneri strain SFL124 has been used as the parental strain for the development of recombinant vaccines expressing multiple O-antigen structures. During the development of one such multivalent vaccine, a region of gtrII homology was found in SFL124. Sequencing and analysis of this region revealed the presence of an insertion element interrupted serotype 2a serotype-conversion locus in the serotype Y vaccine strain SFL124. The data presented suggests that SFL124 has derived from a serotype 2a background.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEMS Immunology and Medical Microbiology - Volume 45, Issue 2, 1 August 2005, Pages 285-289
نویسندگان
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