کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9278078 | 1222829 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Role of anti-β-glucan antibody in host defense against fungi
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We have recently detected an anti-β-glucan antibody in normal human and normal mouse sera. The anti-β-glucan antibody showed reactivity to pathogenic fungal Aspergillus and Candida cell wall glucan. Anti-β-glucan antibody could bind whole Candida cells. It also enhanced the candidacidal activity of macrophages in vitro. The anti-β-glucan antibody titer of DBA/2 mice intravenously administered either Candida or Aspergillus solubilized cell wall β-glucan decreased remarkably dependent on dose. Moreover, in deep mycosis patients, the anti-β-glucan antibody titer decreased, and this change correlated with clinical symptoms and other parameters such as C-reactive protein. It was suggested that the anti-β-glucan antibody formed an antigen-antibody complex and participated in the immune response as a molecule recognizing pathogenic fungi.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEMS Immunology and Medical Microbiology - Volume 44, Issue 1, 1 April 2005, Pages 99-109
Journal: FEMS Immunology and Medical Microbiology - Volume 44, Issue 1, 1 April 2005, Pages 99-109
نویسندگان
Ken-ichi Ishibashi, Masaharu Yoshida, Iwao Nakabayashi, Hiroyasu Shinohara, Noriko N. Miura, Yoshiyuki Adachi, Naohito Ohno,