کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9282924 | 1224991 | 2005 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chimeric epitopes delivered by polymeric synthetic linear peptides induce protective immunity to malaria
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کلمات کلیدی
MSP-1O.DIFAmAbCTLCSPPlasmodium yoeliiIL-4IFN-γPlasmodium bergheiLPCMonoclonal antibody - آنتی بادی مونوکلونالB cell epitope - اپیتوپ سلول BInterleukin 4 - اینترلوکین 4optical densities - تراکم نوریT cell epitope - تومور سلول TProtection - حفاظتDelivery - زایمانCytotoxic T lymphocytes - لنفوسیت های T سیتوتوکسیکMalaria - مالاریاVaccine - واکسنCircumsporozoite protein - پروتئین CircumsporozoiteMerozoite surface protein 1 - پروتئین سطح مرووزیتی 1Plasmodium vivax - پلاسمودیوم ویواکسPeptides - پپتیدهاInterferon gamma - گاما اینترفرون
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Chimeric epitopes delivered by polymeric synthetic linear peptides induce protective immunity to malaria Chimeric epitopes delivered by polymeric synthetic linear peptides induce protective immunity to malaria](/preview/png/9282924.png)
چکیده انگلیسی
Polymeric linear peptide chimeras (LPCs) that incorporate Plasmodium vivax promiscuous T cell epitopes and the P. falciparum circumsporozoite protein B cell epitope have been shown to induce a high level of immunogenicity and overcome genetic restriction when tested as vaccine immunogens in BALB/c mice. The present study evaluates the biological relevance of several LPCs using a well characterized rodent malaria model. Polymeric peptide constructs based on P. berghei and P. yoelii sequences, and orthologous to the human malaria sequences included in the original LPCs, were designed and tested for immunogenicity in mice of different H-2Â haplotypes. We demonstrate that robust immune responses are induced and that peptides containing the orthologous rodent Plasmodium sequences exhibited similar immunogenic capabilities. Unique to this report, we show that LPCs can also prime MHC class I-restricted cytotoxic T lymphocytes (CTLs) and, most relevantly, that a peptide construct prototype incorporating single B, T and CTL epitopes induced protection against an experimental challenge with P. berghei or P. yoelii sporozoites. Collectively, these results suggest that polymeric polypeptide chimeras can be used as a platform to deliver subunit vaccines.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbes and Infection - Volume 7, Issue 13, October 2005, Pages 1324-1337
Journal: Microbes and Infection - Volume 7, Issue 13, October 2005, Pages 1324-1337
نویسندگان
Ivette Caro-Aguilar, Stacey Lapp, Jan Pohl, Mary R. Galinski, Alberto Moreno,