کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9296470 | 1233534 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evaluation of interferon-γ, interferon-γ-inducing cytokines, and interferon-γ-inducible chemokines in tuberculous pleural effusions
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کلمات کلیدی
PPDmonokine induced by interferon-gammaI-TACELRTh1IP-10AFBROCAUC - AUCMIG - MEadenosine deaminase - آدنوزین دآمینازacid-fast bacillus - اسید سریع باسیلinterferon - اینترفرونIFN - اینترفرون هاinterleukin - اینترلوکینELISA - تست الیزاEnzyme-linked immunosorbent assay - تست الیزاlactate dehydrogenase - لاکتات دهیدروژناز LDH - لاکتات دهیدروژناز به صورت مختصر شده LDH purified protein derivative - مشتق شده پروتئین خالصT-helper type 1 - نوع T-helper 1polymerase chain reaction - واکنش زنجیره ای پلیمرازPCR - واکنش زنجیرهٔ پلیمرازADA - وجود داردreceiver-operator characteristic - ویژگی گیرنده-اپراتور
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Evaluation of interferon-γ, interferon-γ-inducing cytokines, and interferon-γ-inducible chemokines in tuberculous pleural effusions Evaluation of interferon-γ, interferon-γ-inducing cytokines, and interferon-γ-inducible chemokines in tuberculous pleural effusions](/preview/png/9296470.png)
چکیده انگلیسی
Tuberculous and malignant pleural effusions are representative of lymphocytic pleural effusions. In tuberculous pleurisy, especially, T-helper type 1 (Th1) cytokines are dominant, containing, for example, high concentrations of interferon (IFN)-γ. We focused on cytokines that induced expression of IFN-γ and Th1 cell-specific CXC chemokines induced by IFN-γ. We also evaluated the diagnostic utility of these markers in tuberculous pleural effusions. Forty-three patients with pleural effusions (11 with tuberculous pleuritis, 32 with malignant pleuritis) were studied. We measured the pleural concentrations of IFN-γ, IFN-γ-inducing cytokines (interleukin [IL]-12 and IL-18), and IFN-γ-inducible chemokines (interferon-gamma-inducible protein of 10-kD [IP-10], monokine induced by interferon-gamma [Mig], and interferon-inducible T-cell α chemoattractant [I-TAC]). Our results demonstrate that the concentrations of IFN-γ, IFN-γ-inducing cytokines, and IFN-γ-inducible chemokines were all higher in tuberculous pleural effusions than in malignant pleural effusions. Also, IFN-γ was significantly correlated with IL-12, Mig, and I-TAC. Moreover, receiver-operator-characteristic (ROC) analysis demonstrated that IFN-γ produced a greater area under the ROC curve than any other factor. We conclude that the concentrations of IFN-γ, cytokines that induced expression of IFN-γ, and chemokines induced by IFN-γ in tuberculous pleural effusion were all increased. The Th1 chemokines we examined, especially IP-10, are comparable to IFN-γ as diagnostic markers of tuberculous and malignant pleural effusions, although IFN-γ is the most valuable.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Laboratory and Clinical Medicine - Volume 145, Issue 2, February 2005, Pages 88-93
Journal: Journal of Laboratory and Clinical Medicine - Volume 145, Issue 2, February 2005, Pages 88-93
نویسندگان
Masakazu Okamoto, Tsutomu Kawabe, Yasumasa Iwasaki, Toru Hara, Naozumi Hashimoto, Kazuyoshi Imaizumi, Yoshinori Hasegawa, Kaoru Shimokata,