Are There Differences in the Symptoms that Respond to a Selective Serotonin or Norepinephrine Reuptake Inhibitor?

Reboxetine and fluoxetine appear to have similar effects on depressive symptoms. These data suggest that NE and 5-HT selective antidepressant drugs act through the same final common pathway and challenge the belief that symptom differences are useful for antidepressant selection.