Electroconvulsive shock decreases binding to 5-HT2 receptors in nonhuman primates: An in vivo positron emission tomography study with [18F]setoperone

These results show for the first time in a primate species that chronic ECS decreases binding to 5-HT2 receptors and indicate that 5-HT2 receptor downregulation may be a common effect of both pharmacologic and nonpharmacologic antidepressant treatments.