Antipsychotics alter the protein expression levels of β-catenin and GSK-3 in the rat medial prefrontal cortex and striatum

Targeting of β-catenin and GSK-3 is a common feature of antipsychotics regardless of class and appears to be mediated by D2 dopamine receptors. Therefore changes in β-catenin and GSK-3 may represent one of the mechanisms through which antipsychotics are able to exert behavioral changes.