Topological analysis of the electronic charge density in nucleoside analogues derivatives of the AZT. Effects of X-H⋯O and X-H⋯F intramolecular H-bonds

Comparing the results obtained in all the nucleosides derivatives studied here with the ones results in both conformations of 3′-N3-C-FMAU, 13, biologically inactive compound, allows us to know the characteristic of the intramolecular hydrogen bonds in nucleoside analogues derivatives of AZT in greater detail and relate them to the conformational and stereo-electronics requirements necessary to produce the biological activity.