QSAR studies of 20(S)-camptothecin analogues as antitumor agents

In this paper, the topological molecular descriptors were introduced to the QSAR studies of three types of 20(S)-camptothecin analogues and good relationships between the biological activity and the descriptors of the substitutions of those compounds were obtained with multiple regression. These QSAR models have good predictive ability, which will be of great benefit to our future design and synthesis of novel highly potent antitumor camptothecin analogues and be helpful for proving or improving the action mechanism supposed.